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Shëndeti

Fantastic news is coming! Scientists discover genetic trigger that can cure hair loss

Fantastic news is coming! Scientists discover genetic trigger that can cure hair

A team from the University of California Irvine (UCI) in the US and partners from other countries have discovered a molecule – called SCUBE3 – that causes vigorous hair growth in men and women.

They claim it can put an end to baldness and hair loss, including alopecia, for good. The study, published in Developmental Cell, revealed exactly how dermal papilla cells, found at the end of each hair follicle, stimulate new growth.

Although it was already well known that dermal papilla cells play a major role in controlling hair growth, the activating molecules involved were previously "poorly understood".

Study author and UCI professor Maksim Plikus explained: "At different times during the life cycle of the hair follicle, the same dermal papilla cells can send signals that either keep the follicles dormant or trigger new hair growth. cloud.

"We found that the signaling molecule SCUBE3, which dermal papilla cells naturally produce, is the messenger used to 'tell' neighboring hair stem cells to start dividing, which heralds the start of new hair growth. young people".

Production of activating molecules by dermal papilla cells is "critical" for efficient hair growth in both mice and humans.

In people with androgenetic alopecia – also known as pattern hair loss – the dermal papilla cells malfunction, greatly reducing the normally abundant activating molecules.

To investigate this, the team studied a mouse with hyperactivated dermal papilla cells and excess hair.

UCI researcher Yingzi Liu said: "Study of this mouse model allowed us to identify SCUBE3 as the previously unknown signaling molecule that can promote excessive hair growth."

Further tests then proved that SCUBE3 activates hair growth in human follicles. The researchers microinjected SCUBE3 into mouse skin into which human scalp follicles had been transplanted, stimulating new growth in both the dormant human follicles and surrounding mouse follicles.

Team member Christian Guerrero-Juarez added: "These experiments provide proof of principle that SCUBE3 or derived molecules may be a promising therapy for hair loss."